Block of 5-HT2 Receptors Enhances Hippocampal Long-Term Potentiation
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Abstract:
The effect of endogenous serotonin on long-term potentiation (LTP) in region CAI was studied by blocking 5-HT2 receptors with ketanserin in rat hippocampal slices. Such a block significantly en-hanced long-term potentiation of the CAI population spike induced by high frequency stimulation of the schaffer collateral/ commissural pathway. This implies that serotonin acts on 5-HT2 receptors in CAI to repress long-term potentiation.
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Journal title
volume 2 issue 3
pages 129- 131
publication date 1998-07
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